1 00:00:00,500 --> 00:00:03,590 PROFESSOR: Eating is one of the great pleasures and necessities 2 00:00:03,590 --> 00:00:04,690 of life. 3 00:00:04,690 --> 00:00:08,950 And to enjoy everything from energy bars to apples, 4 00:00:08,950 --> 00:00:10,690 we rely on one part of our bodies 5 00:00:10,690 --> 00:00:13,006 to do an important job-- our teeth. 6 00:00:13,006 --> 00:00:14,720 [TEETH CHATTERING] 7 00:00:14,720 --> 00:00:17,460 Teeth are the hardest substances in our bodies. 8 00:00:17,460 --> 00:00:19,230 They're harder than our bones. 9 00:00:19,230 --> 00:00:21,170 And they're even harder than iron or steel. 10 00:00:21,170 --> 00:00:23,770 So why doesn't our jaw just crumble 11 00:00:23,770 --> 00:00:25,240 under all of those forces? 12 00:00:25,240 --> 00:00:27,360 Between your tooth and your jawbone, 13 00:00:27,360 --> 00:00:30,030 there is a specialized piece of tissue called the Periodontal 14 00:00:30,030 --> 00:00:33,400 Ligament, or PDL for short. 15 00:00:33,400 --> 00:00:35,790 The PDL can easily absorb the normal forces 16 00:00:35,790 --> 00:00:39,650 that a tooth experiences when we chew, say, an apple, cushioning 17 00:00:39,650 --> 00:00:41,940 or protecting our jawbone from our teeth. 18 00:00:41,940 --> 00:00:45,180 Teeth sound like they're already perfectly designed. 19 00:00:45,180 --> 00:00:47,720 But sometimes, we really need to force them 20 00:00:47,720 --> 00:00:50,330 in a certain direction, like with braces. 21 00:00:50,330 --> 00:00:53,410 As the braces slowly force the teeth to move, 22 00:00:53,410 --> 00:00:55,610 the PDL is squeezed in one direction 23 00:00:55,610 --> 00:00:57,220 and stretched in the other. 24 00:00:57,220 --> 00:00:59,270 To make room, the mechanoreceptors 25 00:00:59,270 --> 00:01:02,810 in the PDL trigger cells called osteoclasts 26 00:01:02,810 --> 00:01:04,970 that actually come in and dissolve part 27 00:01:04,970 --> 00:01:06,690 of your jaw to make extra room. 28 00:01:06,690 --> 00:01:09,180 The mechanoreceptors also trigger another kind of cell 29 00:01:09,180 --> 00:01:11,330 called an osteoblast, which comes in 30 00:01:11,330 --> 00:01:13,500 and builds up part of the jawbone. 31 00:01:13,500 --> 00:01:16,550 This allows the PDL to get back into its regular cushioning 32 00:01:16,550 --> 00:01:19,560 shape, thus holding the tooth securely in position. 33 00:01:19,560 --> 00:01:23,400 So if braces use osteoblasts to physically reposition teeth 34 00:01:23,400 --> 00:01:25,050 for cosmetic reasons, what if we want 35 00:01:25,050 --> 00:01:27,640 to use them to replace things in our bodies? 36 00:01:27,640 --> 00:01:29,620 Dental implants replace teeth that 37 00:01:29,620 --> 00:01:32,430 are damaged or missing to restore chewing function. 38 00:01:32,430 --> 00:01:34,130 Your jaw isn't the only place where 39 00:01:34,130 --> 00:01:35,860 these osteoblasts and osteoclasts are 40 00:01:35,860 --> 00:01:37,450 altering your bone structure. 41 00:01:37,450 --> 00:01:39,960 In fact, this bony remodeling process 42 00:01:39,960 --> 00:01:42,050 is happening throughout your entire body. 43 00:01:42,050 --> 00:01:44,800 And these implants aren't just limited to teeth. 44 00:01:44,800 --> 00:01:49,450 Doctors can replace knees, hips, even spinal discs. 45 00:01:49,450 --> 00:01:51,740 And MIT engineers are using the properties 46 00:01:51,740 --> 00:01:54,940 of osteoblasts and osteoclasts that are already in our bodies 47 00:01:54,940 --> 00:01:57,560 to create a chemical coating for these implants. 48 00:01:57,560 --> 00:01:59,410 Just like in a mouth with braces, 49 00:01:59,410 --> 00:02:01,630 this coating helps create natural bone 50 00:02:01,630 --> 00:02:03,650 to help lock the implant into place. 51 00:02:03,650 --> 00:02:06,850 Right now, these implants are designed 52 00:02:06,850 --> 00:02:09,064 to have the exact same functionality as the parts 53 00:02:09,064 --> 00:02:10,022 that they're replacing. 54 00:02:13,030 --> 00:02:15,700 But scientists are already developing implants 55 00:02:15,700 --> 00:02:19,340 to improve the performance of our bodies and brains. 56 00:02:19,340 --> 00:02:23,880 So at that point, would we be more machine than human?