| WEEK # | TOPICS | READINGS |
|---|---|---|
| 1 |
Introduction to the course |
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| 2 |
Uncontrolled proliferation: Sonic hedgehog signaling in the developing brain and brain tumors |
Wechsler-Reya, R. J., and M. P. Scott. "Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog." Neuron 22 (1999): 103-114. Berman, D. M., et al. "Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade." Science 297 (2002): 1559-61. |
| 3 |
Proto-oncogenes at the root of developmental disorders and cancer: the example of K-ras |
Hingorani, S. R., et al. "Preinvasive and Invasive Ductal Pancreatic Cancer and its early Detection in the Mouse." Cancer Cell 4 (2003): 437-50. Schubbert S., et al. "Germline KRAS Mutations Cause Noonan Syndrome." Nat Genet 38 (2006): 331-6. |
| 4 |
To live or to die: the general principles of apoptosis |
Ellis, H. M., and H. R. Horvitz. "Genetic Control of Programmed Cell Death in the Nematode C. Elegans." Cell 44 (1986): 817-29. Mathas S., et al. "c-FLIP Mediates Resistance of Hodgkin/Reed-Sternberg Cells to Death Receptor-induced Apoptosis." J Exp Med 199 (2004): 1041-52. |
| 5 |
Liver apoptosis: the case of NF-kappaB |
Rudolph D., W. C. Yeh, A. Wakeham, B. Rudolph, D. Nallainathan, J. Potter, A. J. Elia, and T. W. Mak. "Severe Liver Degeneration and Lack of NF-kappaB Activation in NEMO/IKKgamma-deficient Mice." Genes Dev 14 (2000): 854-62. Luedde, T., N. Beraza, V. Kotsikoris, G. van Loo, A. Nenci, R. De Vos, T. Roskams, C. Trautwein, and M. Pasparakis. "Deletion of NEMO/IKKgamma in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma." Cancer Cell 11 (2007): 119-32. |
| 6 |
Stem cells and self-renewal |
Reya, T., A. W. Duncan, L. Ailles, J. Domen, D. C. Scherer, K. Willert, L. Hintz, R. Nusse, and I. L. Weissman. "A Role for Wnt Signaling in Self-renewal of Hematopoietic Stem Cells." Nature 423 (2003): 409-14. Morin, P. J., A. B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K. W. Kinzler. "Activation of Beta-catenin-Tcf Signaling in Colon Cancer by Mutations in Beta-catenin or APC." Science 275 (1997): 1787-90. |
| 7 |
Angiogenesis: the formation of new blood vessels and the role of VEGF |
Gerber, H. P., et al. "VEGF is Required for Growth and Survival in Neonatal Mice." Development 126 (1999): 1149-59. Inoue, M., J. H. Hager, N. Ferrara, H. P. Gerber, and D. Hanahan. "VEGF-A has a Critical, Nonredundant Role in Angiogenic Switching and Pancreatic Cell Carcinogenesis." Cancer Cell 1 (2002): 193-202. |
| 8 |
Metastasis, the lethal spread of cancer |
Leptin, M. "Twist and Snail as Positive and Negative Regulators During Drosophila Mesoderm Development." Genes Dev 5 (1991): 1568-76. Yang, J., et al. "Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis." Cell 117 (2004): 927-39. |
| 9 |
Metastasis part II: the case of TGF-Beta |
Bardeesy, N., et al. "Smad4 is Dispensable for Normal Pancreas Development yet Critical in Progression and Tumor Biology of Pancreas Cancer." Genes Dev 20 (2006): 3130-46. Cui, W., D. J. Fowlis, S. Bryson, E. Duffie, H. Ireland, A. Balmain, and R. J. Akhurst. "TGFbeta1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice." Cell 86 (1996): 531-42. |
| 10 |
Growth factor signaling: from normal function to clinical treatment |
Miettinen, P. J., J. E. Berger, J. Meneses, Y. Phung, R. A. Pedersen, Z. Werb, and R. Derynck. "Epithelial Immaturity and Multiorgan Failure in Mice Lacking Epidermal Growth Factor Receptor." Nature 376 (1995): 337-41. Lynch, T. J., et al. "Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Nonsmall-cell Lung Cancer to Gefitinib." N Engl J Med 350 (2004): 2129-39. |
| 11 |
MicroRNAs in development and cancer |
Ventura, A., et al. "Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17 through 92 Family of miRNA Clusters." Cell 132 (2008): 875-86. He, L., et al. "A MicroRNA Polycistron as a Potential Human Oncogene." Nature 435 (2005): 828-33. |
| 12 |
Final class |