Protein Folding Problem

Protein folding factors.

Model pathway for a newly synthesized polypeptide chain emerging from the ribosome and folding to its native state, as well as an off-pathway inactive aggregated state. (Image by Prof. Jonathan King.)


MIT Course Number

7.88J / 7.24J / 5.48J / 10.543J

As Taught In

Fall 2007


Undergraduate / Graduate

Translated Versions


Cite This Course

Course Features

Course Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Other OCW Versions

Archived versions: Question_avt logo

King, Jonathan. 7.88J Protein Folding Problem, Fall 2007. (MIT OpenCourseWare: Massachusetts Institute of Technology), (Accessed). License: Creative Commons BY-NC-SA

For more information about using these materials and the Creative Commons license, see our Terms of Use.