1 00:00:05,346 --> 00:00:07,220 JOANNE STUBBE: The morphological unit of life 2 00:00:07,220 --> 00:00:11,200 is the cell, whether you're a flea or you're an elephant. 3 00:00:11,200 --> 00:00:12,170 Right? 4 00:00:12,170 --> 00:00:17,500 And we all have water as the major solvent. 5 00:00:17,500 --> 00:00:22,780 We all have the same biological molecules that 6 00:00:22,780 --> 00:00:26,680 play a major role inside our bodies, like sugar or fat, 7 00:00:26,680 --> 00:00:29,860 or amino acids, or nucleotides. 8 00:00:29,860 --> 00:00:35,470 We all have the same ways of making reactions 9 00:00:35,470 --> 00:00:39,100 work fast enough so they can succeed inside the cell, 10 00:00:39,100 --> 00:00:44,050 and controlling the specificity, and they're conserved 11 00:00:44,050 --> 00:00:46,960 from bacteria to humans. 12 00:00:46,960 --> 00:00:52,120 We all use the same vitamins on your vitamin bottle. 13 00:00:52,120 --> 00:00:55,810 And those are also conserved in general 14 00:00:55,810 --> 00:00:59,140 from bacteria to humans. 15 00:00:59,140 --> 00:01:02,680 And we also all have the same major regulatory mechanisms, 16 00:01:02,680 --> 00:01:06,430 although as you go from prokaryotes to eukaryotes, 17 00:01:06,430 --> 00:01:08,600 things get more complex. 18 00:01:08,600 --> 00:01:11,000 And so what we cover in the course is, in fact, 19 00:01:11,000 --> 00:01:13,390 most of the things we talk about are bacterial systems 20 00:01:13,390 --> 00:01:18,250 because they're better studied but can be extrapolated 21 00:01:18,250 --> 00:01:19,690 between the two systems. 22 00:01:22,360 --> 00:01:25,870 So are these things ordered inside the cell? 23 00:01:25,870 --> 00:01:27,850 And how do you study them inside the cell? 24 00:01:27,850 --> 00:01:31,570 That's the major focus of a biochemist. 25 00:01:31,570 --> 00:01:33,780 You want to understand things at the molecular level, 26 00:01:33,780 --> 00:01:36,430 but then you need to understand what 27 00:01:36,430 --> 00:01:39,160 you see at the molecular level, how does that relate to what's 28 00:01:39,160 --> 00:01:41,000 going on inside the cell? 29 00:01:41,000 --> 00:01:43,330 And so you need to go back and forth 30 00:01:43,330 --> 00:01:46,390 between inside the cell and understanding 31 00:01:46,390 --> 00:01:49,390 the chemical and physical principles by which all 32 00:01:49,390 --> 00:01:51,660 the reactions work.