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JOANNE STUBBE: The way we teach
the course is we show them

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that all of these
chemical transformations

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can be described by 10
pretty simple steps.

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And if you understand
the basic chemistry

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of these simple steps, you can
really understand almost all

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of the kinds of interconversions
you see and basic metabolism.

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And what you'll see is while
this looks overwhelming,

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really, with a few
central pathways,

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which is what we focus on
in this course-- glycolysis,

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fatty acid oxidation,
biosynthesis,

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sugar biosynthesis as well as
degradation, the Krebs cycle,

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which feeds into the
respiratory chain--

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knowing those
central reactions--

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almost everything in
metabolism feeds in and out

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of these pathways.

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And so then, it
really is a question

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of what is the
environment like and how

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do you enhance
breakdown of sugar

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under the appropriate
environment

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versus synthesize sugar under
a different environment.

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So then it's a
question of regulation.

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So what you're going
to learn in this course

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is really focused on
central metabolism.

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And it doesn't
matter whether you

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study a bacteria or a human,
the central metabolism

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is pretty much the same.

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The thing that's different
is the detailed regulation

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and the complexity
of the regulation.

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And we don't really talk that
much about regulation in 5.07.

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What we do is
introduce you to five

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or six basic regulatory
mechanisms that

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are used over and over again.

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But then, regulation is
really distinct, even

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between organisms.

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And so then that becomes
much more complicated.

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And when you go off and
become a biochemist,

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you've got to study
your own system

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and figure out what
the environment is.