Prof. Ioannis Yannas
Prof. Myron Spector
HST.523J / 2.785J / 3.97J / 20.411J
Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.
Yannas, Ioannis, and Myron Spector. HST.523J Cell-Matrix Mechanics, Spring 2004. (MIT OpenCourseWare: Massachusetts Institute of Technology), http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004 (Accessed). License: Creative Commons BY-NC-SA