Lecture Notes

I. Principles Of Implant Design (Working Paradigms)
1 Clinical Problems Requiring Implants for Solution I. V. Yannas / M. Spector

Overview Slides (PDF - 1.2 MB)

Four Design Principles for Medical Devices (PDF)

2 Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices I. V. Yannas / M. Spector  
3 The Missing Organ and its Replacement I. V. Yannas The Problem of the Missing Organ (PDF)
4 Criteria for Materials Selection I. V. Yannas  
5 Tissue Engineering I: Scaffolds M. Spector

Tissue Engineering I: Overview (PDF - 1.4 MB)

Tissue Engineering II: Scaffolds (PDF - 1.4 MB)

6 Tissue Engineering II: Cells and Regulators M. Spector

Tissue Engineering III: Growth Factors and Genes (PDF - 1.3 MB)

Tissue Engineering IV: Stem Cells (PDF - 1.2 MB)

7 Case Study of Organ Regeneration I. V. Yannas Design Case Study: Device for Partial Regeneration of Skin (PDF)
II. Design Parameters
8 Design Specifications: Biomaterials Survey M. Spector

Biomaterials Survey (PDF)

Implant Fixation, Mechanical Stability and Modulus Matching (PDF - 1.2 MB)

9 Biocompatibility: Local and Systemic Effects M. Spector Biocompatibility (PDF - 1.3 MB)
10 Design Specifications: Tissue Bonding and Modulus Matching M. Spector  
11 Degradation of Devices: Natural and Synthetic Polymers I. V. Yannas  
12 Biocompatibility: Scar Formation and Contraction I. V. Yannas Scar Formation Around Implants (PDF)
13 Degradation of Devices: Corrosion and Wear M. Spector Degradation of Devices: Corrosion and Wear (PDF)
14 Federal Regulation of Devices I M. Spector

Federal Regulation of Medical Devices (PDF - 1.2 MB)

Recommended Biocompatibility Testing and Regulation of Tissue Engineered Products (PDF - 1.0 MB)

Summary of Federal Regulatory Issues and Clinical Trials (PDF - 1.1 MB)

15 Oral Presentations of Proposals for Design II I. V. Yannas / M. Spector  
16 Federal Regulation of Devices II M. Spector  
III. Design Solution In-use
17 Scaffolds for Cartilage Repair S. Vickers Statistics: Type I and Type II errors (PDF)
18 Implants for Bone M. Spector Bone Substitute Materials and Tissue Engineering (PDF - 1.4 MB)
19 Implants for Plastic Surgery Dr. D. P. Orgill  
20 Cardiovascular Prostheses: Heart Valves and Blood Vessels Dr. F. Schoe  
21 Devices for Nerve Regeneration I. V. Yannas  
22 Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk M. Spector  
23 Dental and Otologic Implants M. Spector Dental Tissue Engineering (PDF)
24 Other Devices: Spinal Cord, Heart Lung M. Spector  
25 Final Oral Presentation of Designs (Mock FDA Panel)