Introduction (PDF)

Discher, Dennis E., Paul Janmey, et al. "Tissue Cells Feel and Respond to the Stiffness of their Substrate." Science 310, no. 5751 (2005): 1139–43.

Engler, Adam J., Shamik Sen, et al. "Matrix Elasticity Directs Stem Cell Lineage Specification." Cell 126, no. 4 (2006): 677–89.

Tissue Structures and Unit Cell Processes (PDF - 3.9MB)

Vale, Ronald D., and Ronald A. Milligan. "The Way Things Move: Looking under the Hood of Molecular Motor Proteins." Science 288, no. 5463 (2000): 88–95.

Stossel, Thomas P. "On the Crawling of Animal Cells." Science 260, no. 5111 (1993): 1086–94.

Hinz, Boris, Giuseppe Celetta, et al. "Alpha-smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity." Molecular Biology of the Cell 12, no. 9 (2001): 2730–41.

Cell-Matrix Interaction: Integrins and Fibronexus (PDF - 3.9MB)

Ruoslahti, Erkki, and Michael D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (1987): 491–97.

Wang, J. H-C., and B. P. Thampatty. "An Introductory Review of Cell Mechanobiology." Biomechanics and Modeling in Mechanobiology 5, no. 1 (2006): 1–16.

Extracellular Matrix Molecules

[No reading.]

Sweeney, Shawn M., Joseph P. Orgel, et al. "Candidate Cell and Matrix Interaction Domains on the Collagen Fibril, the Predominant Protein of Vertebrates." Journal of Biological Chemistry 283, no. 30 (2008): 21187–97.

Mechanical Behavior

[No reading.]

[There are no additional readings.]
Effects of Exogenous Mechanical Forces (PDF)

Jessop, H. L., M. Sjöberg, et al. "Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells." Journal of Bone and Mineral Research 16, no. 6 (2001): 1045–55.

Banes, Albert J., Mari Tsuzaki, et al. "Mechanoreception at the Cellular Level: The Detection, Interpretation, and Diversity of Responses to Mechanical Signals." Biochemistry and Cell Biology 73, no. 7–8 (1995): 349–65.

Davies, Peter F., and S. C. Tripathi. "Mechanical Stress Mechanisms and the Cell. An Endothelial Paradigm." Circulation Research 72, no. 2 (1993): 239–45.

Alenghat, Francis J., and Donald E. Ingber. "Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins." Science STKE 119, no. 6 (2002): pe6.

Schaffer, Jonathan L., Michael Rizen, et al. "Device for the Application of a Dynamic Biaxially Uniform and Isotropic Strain to a Flexible Cell Culture Membrane." Journal of Orthopaedic Research 12, no. 5 (1994): 709–19.

McNeil, Paul L., and Richard A. Steinhardt. "Plasma Membrane Disruption: Repair, Prevention, Adaptation." Annual Review of Cell and Developmental Biology 19, no. 1 (2003): 697–731.

Miyake, Katsuya, and Paul L. McNeil. "Mechanical Injury and Repair of Cells." Critical Care Medicine 31, no. 8 (2003): S496–501.

Rubin, Clinton T., and Lance E. Lanyon. "Osteoregulatory Nature of Mechanical Stimuli: Function as a Determinant for Adaptive Remodeling in Bone." Journal of Orthopaedic Research 5, no. 2 (1987): 300–10.

Endogenous Force Generation by Cells

[No reading.]

Freyman, T. M., I. V. Yannas, et al. "Fibroblast Contraction of a Collagen–GAG Matrix." Biomaterials 22, no. 21 (2001): 2883–91.

———. "Fibroblast Contractile Force is Independent of the Stiffness which Resists the Contraction." Experimental Cell Research 272, no. 2 (2002): 153–62.

Freyman, T. M., I. V. Yannas, et al. "Micromechanics of Fibroblast Contraction of a Collagen–GAG Matrix." Experimental Cell Research 269, no. 1 (2001): 140–53.

Hwang, Kun, Hyung Bo Sim, et al. "Myofibroblasts and Capsular Tissue Tension in Breast Capsular Contracture." Aesthetic Plastic Surgery 34, no. 6 (2010): 716–21.

Ligaments and Tendons

[No reading.]

[There are no additional readings.]

Meniscus and Intervertebral Disc

[No reading.]

Walsh, Andrew J. L., and Jeffrey C. Lotz. "Biological Response of the Intervertebral Disc to Dynamic Loading." Journal of Biomechanics 37, no. 3 (2004): 329–37.

Kasra, Mehran, Vijay Goel, et al. "Effect of Dynamic Hydrostatic Pressure on Rabbit Intervertebral Disc Cells." Journal of Orthopaedic Research 21, no. 4 (2003): 597–603.

Fermor, Beverley, Devon Jeffcoat, et al. "The Effects of Cyclic Mechanical Strain and Tumor Necrosis Factor Alpha on the Response of Cells of the Meniscus." Osteoarthritis and Cartilage 12, no. 12 (2004): 956–62.

Zielinska, B., M. Killian, et al. "Meniscal Tissue Explants Response Depends on Level of Dynamic Compressive Strain." Osteoarthritis and Cartilage 17, no. 6 (2009): 754–60.

Zaleskas, J. M., B. Kinner, et al. "Growth Factor Regulation of Smooth Muscle Actin Expression and Contraction of Human Articular Chondrocytes and Meniscal Cells in a Collagen–GAG Matrix." Experimental Cell Research 270, no. 1 (2001): 21–31.

Articular Cartilage

[No reading.]

[There are no additional readings.]

Hughes-Fulford, Millie. "Signal Transduction and Mechanical Stress." Science STKE 2004, no. 249 (2004): re12.

Turner, Charles H., and Fredrick M. Pavalko. "Mechanotransduction and Functional Response of the Skeleton to Physical Stress: The Mechanisms and Mechanics of Bone Adaptation." Journal of Orthopaedic Science 3, no. 6 (1998): 346–55.

Robling, A. G., K. M. Duijvelaar, et al. "Modulation of Appositional and Longitudinal Bone Growth in the Rat Ulna by Applied Static and Dynamic Force." Bone 29, no. 2 (2001): 105–13.

Burr, D. B., Alexander G. Robling, et al. "Effects of Biomechanical Stress on Bones in Animals." Bone 30, no. 5 (2002): 781–86.

Biomaterials and Electrically and Magnetically Responsive Matrices

[No reading.]

[There are no additional readings.]