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We next discuss
interventions suggested

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by the model developed for
the Framingham Heart Study.

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The first intervention
has to do with drugs

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to lower blood pressure.

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In FDR's time,
hypertension drugs

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were too toxic
for practical use.

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But in the 1950s, the diuretic
chlorothiazide was developed,

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and the Framingham Heart
Study gave Ed Freis

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the evidence needed to argue
for testing effects for blood

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pressure drugs.

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In fact, the Veterans
Administration Trial

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was conducted.

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This was a randomized,
double blind clinical trial,

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that found decreased risk
of coronary heart disease.

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Now, the market for
diuretics worldwide

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is more than a billion dollars.

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Another intervention had to do
with-- to lower cholesterol.

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Despite the Framingham results,
early cholesterol drugs

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were too toxic
for practical use.

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But in the 1970s, the first
statins were developed.

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The study of 4,444
patients with CHD

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revealed that statins
cause a 37% risk

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reduction of a
second heart attack.

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Furthermore, a study of 6,595
men with high cholesterol

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revealed that statins cause a
32% risk reduction in deaths.

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Now, the market for
statins worldwide

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is more than $20 billion.