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JOHN DOLHUN: You got the sock?

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OK.

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So I'm just going to put
the sock in here.

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He's going to catch it.

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[LOUD POPPING NOISE]

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There it goes.

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Let's check his sock out.

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Is it still OK?

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[MUSIC PLAYING]

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NARRATOR: It's day one.

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MIT instructor John Dolhun
introduces the course.

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JOHN DOLHUN: You're going to
learn basic skills that will

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form building blocks in your
future adventures at MIT and

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outside of MIT.

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NARRATOR: That is,
if you pass.

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And what exactly
does that take?

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JOHN DOLHUN: You're going to get
about 14 hours of lecture,

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about 52 to 75 hours of lab.

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We only have two and
a half weeks.

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You have to be able to think out
of the box, be creative,

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and most importantly, be mindful
of your mistakes.

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PHIL: The hoods are
over there...

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NARRATOR: Next, safety
training.

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Remember, for many of the
students this is their first

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time in the lab.

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No flip-flops, no shorts, no
skirts, but most importantly,

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gloves and goggles starting
tomorrow.

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PHIL: They tell you to wear
goggles and everything.

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And you don't really realize the
importance until you have

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a piece of glass flying
at your face.

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NARRATOR: After four hours of
lecture, the students finally

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check into the lab.

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TENGFEI: My name is Tengfei.

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And this is Phil.

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And we will be the TAs
for this class.

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This is all the equipment you
should have in your drawer and

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the cabinet.

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[MUSIC PLAYING]

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AUDIENCE: Oh.

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Nevermind.

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ETHAN: I guess I get the antique
shelf or something.

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But we'll work around it.

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NARRATOR: After checking in, the
students get introduced to

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a technique called
nuclear magnetic

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resonance, or NMR for short.

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NMR helps chemists piece
together a molecule structure.

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The students put their mystery
molecule into a thin tube and

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lower it into a very powerful
magnetic field.

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This forces certain atoms in the
sample to align themselves

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either with or against
the field.

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Aligning with the field
takes less energy.

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So there are a few more
atoms aligned with

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than against the field.

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A pulse of energy makes the
extra atoms aligned with the

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field flip.

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The computer measures how much
energy this takes and produces

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a spectrum.

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The amount of energy it takes
to flip an atom depends on

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what other atoms
are next to it.

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That means you can tell which of
the atoms are connected and

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put together a picture of what
the whole molecule looks like.

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That's the theory.

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But the students are about to
learn that dealing with a real

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live machine is not so simple.

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ANNE RACHUPKA: Awful lot
we're going to go over.

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These are live magnets.

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They are in field
at all times.

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You cannot go anywhere near it
with iPod, iPhone, any USB

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storage devices, no push pins,
no staples, no bobby pins.

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We have our little sample?

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I have taken people to the
hospital because they've put

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an NMR tube through
their hand.

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Definitely don't bring your
wallet anywhere near the

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instrument.

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This costs probably more than
one year tuition to MIT.

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Obviously, this is not
going to work.

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Do not, under any circumstances,
insert your

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sample without the air on.

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You guys have any burning
questions?

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You're all going to be experts
the first time you sit down

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[INAUDIBLE].

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Right?

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LEALIA: We were all like, uh--

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ANTHONY: Mmm.

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ETHAN: Oh dear God.

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JULIE: Can we just not talk
about this anymore?

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NARRATOR: The day
is finally over.

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And it's time to head home.

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IKE: It was pretty intimidating
because I walked

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into this class with all
these smart people.

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ETHAN: I felt, I guess, a
little bit overwhelmed.

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I wasn't exactly sure what
to expect from 5.301.

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EMILY: I didn't expect it
to be this much work.

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I'm kind of doubting whether I
made the right choice to take

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this class.

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ETHAN: Oh my God, what
have I gotten into ?

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ANTHONY: I am going to
fail this class.

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[MUSIC PLAYING]

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SPEAKER: I've always been
a fan of cupcakes.

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But now that they're popular,
I'm a big fan of cupcakes.

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ANTHONY: Oh, can you
make us dessert?

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SPEAKER: No.

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ANTHONY: Why not?

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SPEAKER: What is this, like
an ice cream social?

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[MUSIC PLAYING]