Three steps in the transcription of protein-coding genes. (Image by Prof. David Gifford.)
Instructor(s)
Prof. David Gifford
Prof. Tommi Jaakkola
MIT Course Number
7.90J / 6.874J
As Taught In
Spring 2005
Level
Graduate
Course Description
Course Features
Course Description
The course focuses on casting contemporary problems in systems biology and functional genomics in computational terms and providing appropriate tools and methods to solve them. Topics include genome structure and function, transcriptional regulation, and stem cell biology in particular; measurement technologies such as microarrays (expression, protein-DNA interactions, chromatin structure); statistical data analysis, predictive and causal inference, and experiment design. The emphasis is on coupling problem structures (biological questions) with appropriate computational approaches.