A sketch of the DNA double helix by Francis Crick, one of the discoverers of the structure of DNA. (Courtesy of The Wellcome Trust, License CC-BY.)
Instructor(s)
Prof. Manolis Kellis
MIT Course Number
6.881
As Taught In
Spring 2016
Level
Graduate
Course Description
Course Description
With the growing availability and lowering costs of genotyping and personal genome sequencing, the focus has shifted from the ability to obtain the sequence to the ability to make sense of the resulting information. This course is aimed at exploring the computational challenges associated with interpreting how sequence differences between individuals lead to phenotypic differences in gene expression, disease predisposition, or response to treatment.