| LEC # | TOPICS | KEY DATES |
|---|---|---|
| 1 | Introduction | |
| 2 | Discovery of the Ubiquitin Conjugation System | |
| 3 | Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway | |
| 4 | Protein Degradation in Trafficking Membranes II: Endocytosis and Lysosomal Degradation | |
| 5 | Role of Ubiquitination in Transcriptional Regulation | |
| 6 | Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death | |
| 7 | Ubiquitin-Like Proteins | Assignment 1 due |
| 8 | Functions of the Ubiquitin-Proteasome System in the Immune System | |
| 9 | Ubiquitin and Cancer | |
| 10 | Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases | |
| 11 | More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease | |
| 12 | Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome | |
| 13 | Potential Therapeutic Strategies in Ubiquitin-Related Diseases | Assignment 2 due |
| 14 | Oral Presentations Final Comments and Course Evaluation |