| WEEK # | TOPICS | READINGS |
|---|---|---|
| 1 | Introduction to the Course | No Readings |
| 2 | Mechanobiology of Materials |
Engler, A. J., S. Sen, et al. "Matrix Elasticity Directs Stem Cell Lineage Specification." Cell 126, no. 4 (2006): 677–89. Fu, J., Yang-Kao Wang, et al. "Mechanical Regulation of Cell Function with Geometrically Modulated Elastomeric Substrates." Nature Methods 7 (2010): 733–6. |
| 3 | Controlling Cell Morphology |
Chen, C. S., M. Mrksich, et al. "Geometric Control of Cell Life and Death." Science 276, no. 5317 (1997): 1425–8. Kilian, K. A., B. Bugarija, et al. "Geometric Cues for Directing the Differentiation of Mesenchymal Stem Cells." Proceedings of the National Academy of Sciences of the United States of America 107, no. 11 (2010): 4872–7. |
| 4 | Altering Gene Expression |
Love, K. T., K. P. Mahon, et al. "Lipid-Like Materials for Low-Dose, in Vivo Gene Silencing." Proceedings of the National Academy of Sciences of the United States of America 107, no. 5 (2010): 1864–9. Hu-Lieskovan, S., J. D. Heidel, et al. "Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma." Cancer Research 65 (2005): 8984–92. |
| 5 | Biomimetic Signaling |
Shin, H., S. Jo, et al. "Modulation of Marrow Stromal Osteoblast Adhesion on Biomimetic olio[Poly(Ethylene Glycol) Fumarate] Hydrogels Modified with Arg-Gly-Asp Peptides and a Poly(Ethyleneglycol) Spacer." Journal of Biomedical Materials Research Part A 61, no. 2 (2002): 169–79. Storrie, H., M. O. Guler, et al. "Supramolecular Crafting of Cell Adhesion." Biomaterials 28, no. 31 (2007): 4608–18. |
| 6 | Targeting with Nanoparticles |
Farokhzad, O. C., J. Cheng, et al. "Targeted Nanoparticle-Aptamer Bioconjugates for Cancer Chemotherapy in Vivo." Proceedings of the National Academy of Sciences of the United States of America 103, no. 16 (2006): 6315–20. Kievit, F. M., O. Veiseh, et al. "Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma." ACS Nano 4, no. 8 (2010): 4587–94. |
| 7 | Materials for Vaccination |
Manolova, V., A. Flace, et al. "Nanoparticles Target Distinct Endritic Cell Populations According to Their Size." European Journal of Immunology 38, no. 5 (2008): 1404–13. Scott, E. A., A. Stano, et al. "Dendritic cell Activation and T Cell Priming with Adjuvant-and Antigen- Loaded Oxidation-Sensitive Polymersomes." Biomaterials 33, no. 26 (2012): 6211–19. |
| 8 | Engineering Vascular Structure |
Niklason, L. E., J. Gao, et al. "Functional Arteries Grown in Vitro." Science 284, no. 5413 (1999): 489–93. Norotte, C., F. S. Marga, et al. "Scaffold-Free Vascular Tissue Engineering Using Bioprinting." Biomaterials 30, no. 30 (2009): 5910–7. |
| 9 | Field Trip | No Readings |
| 10 | Cell-like Materials |
Merkel, T. J., S. W. Jones, et al. "Using Mechanobiological Mimicry of Red Blood Cells to Extend Circulation Times of Hydrogel Microparticles." Proceedings of the National Academy of Sciences of the United States of America 108, no. 2 (2011): 586–91. Hu C. J., L. Zhang, et al. "Erythrocyte Membrane-camouflaged Polymeric Nanoparticles as a Biomimetic Delivery Platform." Proceedings of the National Academy of Sciences of the United States of America 108, no. 27 (2011): 10980–5. |
| 11 | Repairing the Nervous System |
Taylor, S. J., S. E. Sakiyama-Elbert. "Effect of Controlled Delivery of Neurotrophin-3 from Fibrin on Spinal Cord Injury in a Long Term Model." Journal of Controlled Release 116, no. 2 (2006): 204–10. Tysseling-Mattiace, V. M., V. Sahni, et al. "Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury." The Journal of Neuroscience 28, no. 14 (2008): 3814–23. |
| 12 | Final Class | No Readings |