Readings | To Divide or Not To Divide: Control of Cell Cycle and Growth by Extracellular Cues | Biology

Course readings.
WEEK #	TOPICS	READINGS
1	Introduction See the Lecture Summary	No readings
2	Regulation of cell growth by the composition of its environment See the Lecture Summary	Johnston, G. C., C. W. Ehrhardt, et al. "Regulation of Cell Size in the Yeast Saccharomyces cerevisiae." Journal of Bacteriology 137, no. 1 (1979): 1–5. Zetterberg, A., W. Engstrom, et al. "The Relative Effects of Different Types of Growth Factors on DNA Replication, Mitosis, and Cellular Enlargement." Cytometry 5, no. 4 (1984): 368–75.
3	Identification and functional analysis of cell cycle components See the Lecture Summary	Evans, T., E. T. Rosenthal, et al. "Cyclin: A Protein Specified by Maternal mRNA in Sea Urchin Eggs That is Destroyed at Each Cleavage Division." Cell 33, no. 2 (1983): 389–96. Hartwell, L. H. "Sequential Function of Gene Products Relative to DNA Synthesis in the Yeast Cell Cycle." Journal of Molecular Biology 104, no. 4 (1976): 803–17.
4	Bacterial differentiation in response to starvation and cell signaling See the Lecture Summary	Grossman, A. D., and R. Losick. "Extracellular Control of Spore Formation in Bacillus subtilis." Proceedings of the National Academy of Sciences 85, no. 12 (1998): 4369–73. Hahn, J., B. Maier, et al. "Transformation Proteins and DNA Uptake Localize to the Cell Poles in Bacillus subtilis." Cell 122, no. 1 (2005): 59–71.
5	Lab Visit See the Lecture Summary	No readings
6	Genetic regulation of cell fate decision-making in yeast See the Lecture Summary	Deutschbauer, A. M., and R. W. Davis. "Quantitative Trait Loci Mapped to Single-Nucleotide Resolution in Yeast." Nature Genetics 37 (2005): 1333–40. Hongay, C. F., P. L. Grisafi, et al. "Antisense Transcription Controls Cell Fate in Saccharomyces cerevisiae." Cell 127, no. 4 (2006): 735–45.
7	Growth and proliferation promoting pathways I: Ras See the Lecture Summary	Broek, D., T. Toda, et al. "The S. cerevisiae CDC25 Gene Product Regulates the RAS/Adenylate Cyclase Pathway." Cell 48, no. 5 (1987): 789–99. Simon, M. A., D. D. Bowtell, et al. "Ras1 and a Putative Guanine Nucleotide Exchange Factor Perform Crucial Steps in Signaling by the Sevenless Protein Tyrosine Kinase." Cell 67, no. 4 (1991): 701–16.
8	Growth and proliferation promoting pathways II: TOR See the Lecture Summary	Loewith, R., E. Jacinto, et al. "Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control." Molecular Cell 10, no. 3 (2002): 457–68. Korolchuk, V. I., S. Saiki, et al. "Lysosomal Positioning Coordinates Cellular Nutrient Responses." Nature Cell Biology 13 (2011): 453–60.
9	Nutrient control of entry into sporulation See the Lecture Summary	Matsumoto, K., I. Uno, et al. "Initiation of Meiosis in Yeast Mutants Defective in Adenylate Cyclase and Cyclic AMP-Dependent Protein Kinase." Cell 32, no. 2 (1983): 417–23. Sagee, S., A. Sherman, et al. "Multiple and Distinct Activation and Repression Sequences Mediate the Regulated Transcription of IME1, a Transcriptional Activator of Meiosis-Specific Genes in Saccharomyces cerevisiae." Molecular and Cellular Biology 18, no. 4 (1998): 1985–95.
10	Biofilm formation by yeast and bacteria See the Lecture Summary	Lopez, D., M. A. Fischbach, et al. "Structurally Diverse Natural Products that Cause Potassium Leakage Trigger Multicellularity in Bacillus subtilis." Proceedings of the National Academy of Sciences 106, no. 1 (2009): 280–5. Smukalla, S., M. Caldara, et al. "FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast." Cell 135, no. 4 (2008): 726–37.
11	Repression of Gene Transcription in the Absence of Environmental Stimuli See the Lecture Summary	Prelich, G., and F. Winston. "Mutations that Suppress the Deletion of An Upstream Activating Sequence in Yeast: Involvement of a Protein Kinase and Histone H3 in Repressing Transcription in vivo." Genetics 135, no. 3 (1993): 665–76. Garcia-Bassets, I., Y. S. Kwon, et al. "Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors." Cell 128, no. 3 (2007): 505–18.
12	Environmental Control of Cellular Lifespan See the Lecture Summary	Lin, S. J., M. Kaeberlein, et al. "Calorie Restriction Extends Saccharomyces cerevisiae Lifespan by Increasing Respiration." Nature 418 (2002): 344–8. Dang, W., K. K. Steffen, et al. "Histone H4 Lysine 16 Acetylation Regulates Cellular Lifespan." Nature 459 (2009): 802–7.
13	Part 1: Germ Cell Differentiation in Mammals See the Lecture Summary	Lin, Y., M. E. Gill, et al. "Germ Cell-intrinsic and -Extrinsic Factors Govern Meiotic Initiation in Mouse Embryos." Science 322 (2008): 1685–7.
	Part 2: Growth pathways in disease and development See the Lecture Summary	McCoy, M. S., J. J. Toole, et al. "Characterization of a Human Colon/Lung Carcinoma Oncogene." Nature 302, no. 5903 (1983): 79–81.
14	Final Oral Presentations See the Lecture Summary	No readings