| WEEK # | TOPICS | READINGS |
|---|---|---|
| 1 |
Introduction | No readings |
| 2 |
Parkinson's disease I |
Auluck, P. K., H. Y. Chan, et al. "Chaperone Suppression of Alpha-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease." Science 295, no. 5556 (2002): 865–8. Cooper, A. A., A. D. Gitler, et al. "Alpha-synuclein Blocks ER-Golgi Traffic and Rab1 rescues neuron loss in Parkinson's models." Science 313, no. 5785 (2006): 324–8. |
| 3 |
Parkinson's disease II |
Dehay, B., J. Bové, et al. "Pathogenic Lysosomal Depletion in Parkinson's Disease." The Journal of Neuroscience 30, no. 37 (2010): 12535–44. Friedman, L. G., M. L. Lachenmayer, et al. "Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-synuclein and LRRK2 in the Brain." The Journal of Neuroscience 32, no. 22 (2012): 7585–93. |
| 4 |
Alzheimer's disease |
Cohen, E., J. Bieschke, et al. Opposing Activities Protect Against Age-Onset Proteotoxicity. Science 313, no. 5793 (2006): 1604–10. Paquet, D., R. Bhat, et al. "A zebrafish Model of Tauopathy Allows in vivo Imaging of Neuronal Cell Death and Drug Evaluation." The Journal of Clinical Investigation 119, no. 5 (2009): 1382–95. |
| 5 |
Amyotrophic lateral sclerosis |
Tsuda, H., S. M. Han, et al. "The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors." Cell 133, no. 6 (2008): 963–77. Van Hoecke, A., L. Schoonaert, et al. "EPHA4 is a Disease Modifier of Amyotrophic Lateral Sclerosis in Animal Models and in Humans." Nature Medicine 18, no. 9 (2012): 1418–22. |
| 6 |
Lab visit - Huntington's disease model in Drosophila | Field Trip [No Readings] |
| 7 |
Rett Syndrome |
Chahrour, M., S. Y. Jung, et al. "MeCP2, A Key Contributor To Neurological Disease, Activates And Represses Transcription." Science 320, no. 5880 (2008): 1224–9. Adachi, M., A. E. Autry, et al. "MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome." The Journal of Neuroscience 29, no. 13 (2009): 4218–27. |
| 8 |
Fragile X Syndrome |
Dölen, G., E. Osterweil, et al. "Correction of fragile X syndrome in mice." Neuron 56, no. 6 (2007): 955–62. Banerjee, P., B. P. Schoenfeld, et al. "Short- and Long-Term Memory Are Modulated by Multiple Isoforms of the Fragile X Mental Retardation Protein." The Journal of Neuroscience 30, no. 19 (2010): 6782–92. |
| 9 |
Deafness and Blindness |
Pellikka, M., G. Tanentzapf, et al. "Crumbs, the Drosophila Homologue of Human CRB1/RP12, is Essential for Photoreceptor Morphogenesis." Nature 416, no. 6877 (2002): 143–9. Grillet, N., W. Xiong, et al. "Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells." Neuron 62, no. 3 (2009): 375–87. |
| 10 |
Sleep Disorders |
Xu, Y., K. L. Toh, et al. "Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2." Cell 128, no. 1 (2007): 59–70. Raizen, D. M., J. E. Zimmerman, et al. "Lethargus is a Caenorhabditis Elegans Sleep-Like State." Nature 451 (2008): 569–72. |
| 11 |
Wound Healing |
Wang, S., V. Tsarouhas, et al. "The Tyrosine Kinase Stitcher Activates Grainy Head and Epidermal Wound Healing in Drosophila." Nature Cell Biology 11 (2009): 890–5. Niethammer, P., C. Grabher, et al. "A Tissue-Scale Gradient of Hydrogen Peroxide Mediates Rapid Wound Detection in Zebrafish." Nature 459, (2009): 996–9. |
| 12 |
Addiction |
Feng, Z., W. Li, et al. "A C. Elegans Model of Nicotine-Dependent Behavior: Regulation By TRP-Family Channels." Cell 127, no. 3 (2006): 621–33. Bainton, R. J., L. T. Tsai, et al. "Moody Encodes Two GPCRs That Regulate Cocaine Behaviors and Blood-Brain Barrier Permeability in Drosophila." Cell 123, no. 1 (2005). 145-156. |
| 13 |
Metastasis |
Matus, D. Q., X. Y. Li, et al. "In VIVO Identification of Regulators of Cell Invasion Across Basement Membranes." Science Signaling 3, no. 120 (2010): 1–9. Beronja, S., G. Livshits, et al. "Rapid Functional Dissection of Genetic Networks Via Tissue-Specific Transduction and RNAi in Mouse Embryos." Nature Medicine 16 (2010): 821–7. |
| 14 |
Oral presentations and course discussion | No Readings |