| WEEK # | TOPICS | READINGS |
|---|---|---|
| 1 |
Introduction and Overview | No Readings |
| 2 |
What are the Central Components of a Synapse? |
Kittel, R. J., C. Wichmann, et al. "Bruchpilot Promotes Active Zone Assembly, Ca2+ Channel Clustering, and Vesicle Release." Science 312, no. 5776 (2006): 1051–4. Christopherson, K. S., E. M. Ullian, et al. "Thrombospondins are Astrocyte-secreted Proteins that Promote CNS Synaptogenesis." Cell 120, no. 3 (2005): 421–33. |
| 3 |
Molecular Mechanisms of Synapse Formation and Identity |
Chih, B., H. Engelman, et al. "Control of Excitatory and Inhibitory Synapse Formation by Neuroligins." Science 307, no. 5713 (2005): 1324–8. Pinan-Lucarre, B., H. Tu, et al. "C. elegans Punctin Specifies Cholinergic Versus GABAergic Identity of Postsynaptic Domains." Nature 511, no. 7510 (2014): 466–70. |
| 4 |
Canonical Microcircuit: Development and Organizing Principles |
Brown, K. N., S. Chen, et al. "Clonal Production and Organization of Inhibitory Interneurons in the Neocortex." Science 334, no. 6055 (2011): 480–86. Ko, H., S. B. Hofer, et al. "Functional Specificity of Local Synaptic Connections in Neocortical Networks." Nature 473, no. 7345 (2011): 87–91. |
| 5 |
Molecular Basis of Synaptic Plasticity: Pre- and Postsynaptic Mechanisms |
Hayashi, Y., S. H. Shi, et al. "Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction." Science 287, no. 5461 (2000): 2262–7. Bender, V. A., K. J. Bender, et al. "Two Coincidence Detectors for Spike Timing-dependent Plasticity in Somatosensory Cortex." Journal of Neuroscience 26, no. 16 (2006): 4166–77. |
| 6 |
Structural Plasticity: How Does Activity and Experience Change Synaptic Structures? | Lee, H., B. K. Brott, et al. "Synapse Elimination and Learning Rules Co-regulated by MHC Class I H2-Db." Nature 509, no. 7499 (2014): 195–200. Yuan, Q., Y. Xiang, et al. "Light-induced Structural and Functional Plasticity in Drosophila Larval Visual System." Science 333, no. 6048 (2011): 1458–62. |
| 7 |
Diversity of Synapses: Excitation & Inhibition |
Yassin, L., B. L. Benedetti, et al. "An Embedded Subnetwork of Highly Active Neurons in the Neocortex." Neuron 68, no. 6 (2010): 1043–50. Donato, F., S. B. Rompani, et al. "Parvalbumin-expressing Basket-cell Network Plasticity Induced by Experience Regulates Adult Learning." Nature 504, no. 7479 (2013): 272–6. |
| 8 |
Synaptic Learning Rules: Time and Space | Adesnik, H., M. Scanziani. "Lateral Competition for Cortical Space by Layer-specific Horizontal Circuits." Nature 464, no. 7292 (2010): 1155–60. Lamsa, K. P., J. H. Heeroma, et al. "Anti-Hebbian Long-term Potentiation in the Hippocampal Feedback Inhibitory Circuit." Science 315, no. 5816 (2007): 1262–6. |
| 9 |
Correlates of Synaptic and Circuit Function with Behavior | Nabavi, S., R. Fox, et al. "Engineering a Memory with LTD and LTP." Nature 511, no. 7509 (2014): 348–52. Pool, A. H., P. Kvello, et al. "Four GABAergic Interneurons Impose Feeding Restraint in Drosophila." Neuron 83, no. 1 (2014): 164–177. |
| 10 |
Regulatory Networks of Neuropsychiatric Disorders |
Colak, D., N. Zaninovic, et al. "Promoter-bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome." Science 343, no. 6174 (2014): 1002–5. Tyzio, R., R. Nardou, et al. "Oxytocin-mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring." Science 343, no. 6171 (2014): 675–9. |
| 11 |
From Genes to Phenotypes: Animal Models of Human Diseases |
Rothwell, P. E., M. V. Fuccillo, et al. "Autism-associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors." Cell 158, no. 1 (2014): 198–212. Goncalves, J. T., J. E. Anstey, et al. "Circuit Level Defects in the Developing Neocortex of Fragile X Mice." Nature Neuroscience 16 (2013): 903–9. |
| 12 |
Modeling and Manipulating Neurological Disorders: In vivo and in vitro |
Cong, L., F. A. Ran, et al. "Multiplex Genome Engineering Using CRISPR / Cas Systems." Science 339, no. 6121 (2013): 819–23. Espuny-Camacho, I., K. A. Michelsen, et al. "Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits in Vivo." Neuron 77, no. 3 (2013): 440–56. |
| 13 |
Drug Discovery for Neuropsychiatric Disorders: A Visit to Pfizer | Huang, H. S., J. A. Allen, et al. "Topoisomerase Inhibitors Unsilence the Dormant Allele of Ube3a in Neurons." Nature 481, no. 7380 (2012): 185–9. |
| 14 |
Final Assignment and Closing Remarks | No Readings |