Readings


WEEK # TOPICS READINGS
1

Introduction of Instructor and Students and Course Overview

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2

Antimicrobial Peptides in Innate Immune Defense and Their Production

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M. R., Condon, A. Viera, et al. "Induction of a Rat Enteric Defensin Gene by Hemorrhagic Shock." Infection and Immunity 67, no. 9 (1999): 4787–93.

D., Ghosh, E. Porter, et al. "Paneth Cell Trypsin is the Processing Enzyme for Human Defensin-5." Nature Immunology 3, no.6 (2002): 583–90.

3

Antimicrobial Peptides as Double Agents

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P. A., Charp, W. G. Rice, et al. "Inhibition of Protein Kinase C by Defensins, Antibiotic Peptides from Human Neutrophils." Biochemical Pharmacology 37, no. 5 (1988): 951–6.

F., Navid, M. Boniotto, et al. "Induction of Regulatory T Cells by a Murine β-Defensin." The Journal of Immunology 188, no. 2 (2012): 735–43.

4

Folding Matters for Antimicrobial Peptides

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Schroeder B. O., Z. Wu, et al. "Reduction of Disulphide Bonds Unmasks Potent Antimicrobial Activity of Human β-Defensin 1." Nature 469, no. 7330 (2011): 419–23.

Z., Wu, D. Hoover, et al. "Engineering Disulfide Bridges to Dissect Antimicrobial and Chemotactic Activities of Human β-Defensin 3." Proceedings of the National Academy of Sciences of the United States of America 100, no. 15 (2003): 8880–5.

5

Techniques to Study Antimicrobial Peptides

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Koteva K., H. Hong, et al. "A Vancomycin Photoprobe Identifies the Histidine Kinase VanSsc as a Vancomycin Receptor." Nature Chemical Biology 6, no. 5 (2010): 327–9.

Ueberheide, M., A. Fenyö, et al. "Rapid Sensitive Analysis of Cysteine Rich Peptide Venom Components." Proceedings of the National Academy of Sciences of the United States of America 106, no. 17 (2009): 6910–5.

6

Peptides in Biotic Interactions

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Haag A. F., M. Baloban, et al. "Protection of Sinorhizobium Against Host Cysteine-Rich Antimicrobial Peptides is Critical for Symbiosis." PLoS Biology 9, no. 10 (2011): e1001169.

Cullen T. W., W. B. Schofield, et al. "Antimicrobial Peptide Resistance Mediates Resilience of Prominent Gut Commensals During Inflammation." Science 347, no. 6218 (2015): 170–5.

7

Peptide Transporters in Various Organisms

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Y. J., Fei, N. Yoshikatsu, et al. "Expression Cloning of a Mammalian Proton-Coupled Oligopeptide Transporter." Nature 368, no. 6471 (1994): 563–6.

G., L. R. Runti, C. S. Maria, et al. "Functional Characterization of SbmA, a Bacterial Inner Membrane Transporter Required for Importing the Antimicrobial Peptide Bac7 (1-35)." Journal of Bacteriology 195, no. 23 (2013): 5343–51.

8

Peptide Signals in the Brain

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R., Simantov, and S. H. Snyder. "Morphine-like Peptides in Mammalian Brain: Isolation, Structure Elucidation, and Interactions with the Opiate Receptor." Proceedings of the National Academy of Sciences of the United States of America 73, no. 7 (1976): 2515–9.

S. A., Mousa, M. Shakibaei, et al. "Subcellular Pathways of β-Endorphin Synthesis, Processing, and Release from Immunocytes in Inflammatory Pain." Endocrinology 145, no. 3 (2004): 1331–41.

9

Molecules of Hunger and Love

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K., Toshinai, H. Yamaguchi, et al. "Des-acyl Ghrelin Induces Food Intake by a Mechanism Independent of the Growth Hormone Secretagogue Receptor." Endocrinology 147, no. 5 (2006): 2306–14.

Z., Wang, L. J. Young, et al. "Species Differences in Vasopressin Receptor Binding are Evident Early in Development: Comparative Anatomic Studies in Prairie and Montane Voles." Journal of Comparative Neurology 378, no. 4 (1997): 535–46.

10

Epidermal Growth Factors (EGFs) as Signaling Peptides

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S., Felder, K. Miller, et al. "Kinase Activity Controls the Sorting of the Epidermal Growth Factor Receptor Within the Multivesicular Body." Cell 61, no. 4 (1990): 623–34.

B., Dawson, B. L. Mitchell, et al. "Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-induced Conformational Changes in the Dimer Interface." Molecular and Cellular Biology 25, no. 17 (2005): 7734–42.

11

Molecules in Action: Antimicrobial Peptides as Drugs

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V., Miao, M. F. Coëffet-Legal, et al. "Daptomycin Biosynthesis in Streptomyces Roseosporus: Cloning and Analysis of the Gene Cluster and Revision of Peptide Stereochemistry." Microbiology 151, no. 5 (2005): 1507–23.

J. N., Steenbergen, J. T. Alder, et al. "Daptomycin: A Lipopeptide Antibiotic for the Treatment of Serious Gram-Positive Infections." Journal of Antimicrobial Chemotherapy 55, no. 3 (2005): 283–8.

12

Field Trip to Merck Pharmaceuticals

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13

Signaling Peptides as Potential Drugs for Treating Cancers

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J., Chen, X. M. Xu, et al. "Tachyplesin Activates the Classic Complement Pathway to Kill Tumor Cells." Cancer Research 65, no. 11 (2005): 4614–22.

T., Kawamoto, J. L. Mendelsohn, et al. "Relation of Epidermal Growth Factor Receptor Concentration to Growth of Human Epidermoid Carcinoma A431 Cells." Journal of Biological Chemistry 259, no. 12 (1984): 7761–6.

14

Signaling Peptides in Signal Transduction

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H., Daub, F. U. Weiss, et al. "Role of Transactivation of the EGF Receptor in Signaling by G-Protein-Coupled Receptors." Nature 379, no. 6565 (1996): 557–60.

K., Matuoka, M. Shibata, et al. "Cloning of ASH, a Ubiquitous Protein Composed of One Src Homology Region (SH) 2 and Two SH3 Domains, from Human and Rat cDNA Libraries." Proceedings of the National Academy of Sciences of the United States of America 89, no. 19 (1992): 9015–9.

15

Last Day of the Class: Oral Presentations, General Discussion of the Course, and Course Evaluations

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