Crystal structure of the human PLP phosphatase, with pyridoxal 5'-phosphate (PLP), the active form of Vitamin B6, bound in the active site. Image from the RCSB PDB of PDB ID 2CFR (Kang, B.S., et al. Crystal Structure of Human Pyridoxal 5'-Phosphate Phosphatase.) created with Protein Workshop (J.L. Moreland, et al. (2005) The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications. BMC Bioinformatics 6:21).
Instructor(s)
Prof. John Essigmann
Prof. JoAnne Stubbe
Dr. Bogdan Fedeles
Level
Undergraduate
OCW Scholar courses are designed specifically for OCW's single largest audience: independent learners. These courses are substantially more complete than typical OCW courses, and include new custom-created content as well as materials repurposed from previously published courses. Click here for a complete list of OCW Scholar courses.
Course Description
Course Features
- Video lectures
- Captions/transcript
- Special feature - video
- Lecture notes
- Assignments: problem sets with solutions
- Instructor insights
- Resource Index
Course Description
This course examines the chemical and physical properties of the cell and its building blocks, with special emphasis on the structures of proteins and principles of catalysis, as well as the chemistry of organic / inorganic cofactors required for chemical transformations within the cell. Topics encompass the basic principles of metabolism and regulation in pathways, including glycolysis, gluconeogenesis, fatty acid synthesis / degradation, pentose phosphate pathway, Krebs cycle and oxidative phosphorylation.
Course Format
This OCW Scholar course, designed for independent study, is closely modeled on the course taught on the MIT campus. The on-campus course has two types of class sessions: Lectures and recitations. The lectures meet three times each week and recitations meet once a week. In recitations, an instructor or Teaching Assistant elaborates on concepts presented in lecture, working through new examples with student participation, and answers questions.
MIT students who take the corresponding residential class typically report an average of 10–15 hours spent each week, including lectures, recitations, readings, homework, and exams. All students are encouraged to supplement the textbooks and readings with their own research.
The Scholar course has three major learning units, called Modules. Each module has been divided into a sequence of lecture sessions that include:
- Textbook Readings
- Lecture Notes or Storyboards
- A video by Professor JoAnne Stubbe or Professor John Essigmann
- Problem Sets and solutions
To help guide your learning, each of these problem sets are accompanied by Problem Solving Videos where Dr. Bogdan Fedeles solves one of the problems from the set.