Session 3: Enzymes and Catalysis

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Lecture Topics

Definition of a Catalyst Conceptualization of Catalysis using Transition State Theory How has Nature Evolved Enzymes to Lower the Activation Barrier? The Second Important Property of Enzymes is their Specificity

Readings

• Chapter 11: Enzymatic Catalysis
  • General Properties of Enzyme
  • Activation Energy and the Reaction Coordinate
  • Catalytic Mechanisms
  • Serine Proteases

Lecture Video: Enzymes and Catalysis

In this classroom lecture, Professor Stubbe focuses on enzymes as catalysts. She describes the theory and mechanics of catalysis and explains why enzymes are so important.

Lecture Notes

• Enzymes and Catalysis (PDF)

Problem Set & Solutions

• Problem Set 2 (PDF)
• Solutions to Problem Set 2 (PDF)

Problem Solving Video: Problem Set 2, Problem 1: Primary Structure

This problem is about elucidating the primary structure of a protein. Dr. Fedeles uses traditional chemical methods to analyze the data and produce a big picture result. This is the very same process by which discoveries are made.

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