| LEC # | TOPICS | KEY DATES |
|---|---|---|
| Part I: Systems Microbiology - 'The Cell as a Well-stirred Bioreactor' | ||
| 1 | Introduction Michaelis-Menten Kinetics |
|
| 2 | Equilibrium Binding Cooperativity |
|
| 3 | Lambda Phage Multistability |
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| 4 | Multistability (cont.) | |
| 5 | Synthetic Genetic Switches | |
| 6 | Stability Analysis | |
| 7 | Introduction E. coli Chemotaxis | |
| 8 | Fine-tuned versus Robust Chemotaxis Models | Problem set 1 due |
| 9 | Wrapping up Chemotaxis | |
| 10 | Genetic Oscillators | |
| 11 | Genetic Oscillators (cont.) | |
| 12 | Stochastic Chemical Kinetics | Problem set 2 due |
| 13 | Stochastic Chemical Kinetics (cont.) | |
| Part II: Cell Systems Biology - 'The Importance of Diffusion and Gradients for Cellular Regulation' | ||
| 14 | Introduction Cell Systems Biology Fick's Laws |
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| 15 | Local Excitation Global Inhibition Theory |
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| 16 | Local Excitation (cont.) Global Inhibition Theory (cont.) |
Problem set 3 due |
| 17 | Rapid Pole-to-pole Oscillations in E. coli | |
| 18 | Rapid Pole-to-pole Oscillations in E. coli (cont.) | |
| 19 | Models for Eukaryotic Gradient Sensing | Problem set 4 due |
| 20 | Models for Eukaryotic Gradient Sensing (cont.) | |
| 21 | Modeling Cytoskeleton Dynamics | |
| 22 | Modeling Cytoskeleton Dynamics (cont.) | Problem set 5 due |
| Part III: Developmental Systems Biology - 'Building an Organism Starting From a Single Cell' | ||
| 23 | Quorum Sensing | |
| 24 | Final Problem Set Question Hour | |
| 25 | Drosophila Development | Take home final due |