Protein Folding 2: Evolved (Designed) Foldable Proteins

  1. Biomolecular Forces
    • van der Waals interactions
    • Hydrogen bonds
    • Hydrophobic effect
    • Hydrophobic collapse
  2. Protein Folding Problem(s)
    • Anfinsen experiment
    • Thermodynamic hypothesis
    • Levinthal paradox
  3. Thermodynamics of folding
    • Cooperativity
  4. Energy Gap